Compared to most other examples, Mime does not interact frequently with other characters. Despite this, he is easy to get along with and many characters seem to consider him a friend, with a few exceptions like Disco Bear and Flippy.
Cuddles and Mime can be considered friends, as they both attend Flippy's birthday party in Party Animal and help repair Giggles' house in Home Is Where the Hurt Is. Their biggest interaction so far is in A Hole Lotta Love, where Mime tries to warn Cuddles about Sniffles' destructive machine. They also interact in In a Jam, when Cuddles wants to by a guitar but doesn't have any money.
Giggles is also considered a friend of Mime. In Easy Comb, Easy Go, she and Petunia become infatuated with Mime after he wears a wig. Mime also makes Giggles a balloon hat in See What Develops, volunteers to help fix her house in Home Is Where the Hurt Is, and joins her and Petunia for breakfast in Who's to Flame?.
Like other characters, Toothy does not interact often with Mime, but their interactions are always friendly. A particular case would be Mime and Mime Again, where Mime visits an injured Toothy in the hospital and entertains him with tricks (which quickly go horribly wrong).
They are also co-workers at Lumpy's circus in Mime to Five, they both help with setting up Flippy's birthday in Party Animal, they go to see a movie together in YouTube Copyright School, along with Sniffles. Mime also stands next to Toothy in A Change of Heart.
Lumpy and Mime's relationship seems ambiguous, most of the time however Mime is mistreated by him. In Happy Trails Pt. 1, when Mime is choking, Lumpy yells at him. In Mime to Five, Mime attempts to impress Lumpy with his tricks and is forced to clean elephant dung. Mime later tries to get paid from him only to be given back his shovel. In Party Animal, Mime cries when Lumpy swipes away his peanuts. In Dunce Upon a Time, Lumpy keeps Mime as prisoner and kills him accidentally.
On the positive side, they get along in Home Is Where the Hurt Is, as is shown when Lumpy is entertained by Mime.
Mime is close friends with Petunia, the latter appears to be attracted to him in I Heart U and Easy Comb, Easy Go. The two hold hands in Class Act. Petunia also invites Mime and Giggles into her home for breakfast in Who's to Flame?. Mime is however, horrified when Petunia is blindly driving her car in his direction in A Hole Lotta Love.
The closest thing to an interaction between Handy and Mime so far is in Home Is Where the Hurt Is, where both characters (along with a few others) work together to repair Giggles' house.
Mime and Nutty rarely interact. In Party Animal, Mime gets shocked when Nutty accidentally takes his peanuts. Mime is shocked when Nutty steals The Mole's hot dog cart in Chew Said a Mouthful. Mime also sold a lollipop flute to Nutty in In a Jam. They are also treak-or-treating with a group in Remains to be Seen.
While Sniffles and Mime are not rivals in any way, both sides have shown obliviousness to each other. They sit together on a bus in Happy Trails Pt. 1, but Sniffles is asleep and remains so while a choking Mime desperately tries to awaken him. Mime later returns the favor in Mime to Five by letting Sniffles drown in the ocean, instead practicing CPR on an imaginary body.
They are both also seen together in See You Later, Elevator, Something Fishy, and Party Animal but there isn't much interaction in any of these episodes. They do however, go to see a movie together in Youtube Copyright School and Mime is sitting right next to Sniffles. Mime also alerts Sniffles about the fire at Petunia's house in Who's to Flame?.
Their only interaction so far is in Mime to Five. Working at a drive-in, Mime irritates Pop by not responding and subsequently kills him, Cub, and several other customers by turning up the volume of the speaker.
Mime is kind to Flaky despite rarely meeting with her. He offers Flaky a peanut in Party Animal, and, later in the episode, helps her prepare for Flippy's birthday. Mime temporarily saves her life with a trampoline in Mime to Five. He gives Flaky advice when she is a passenger on the plane he works at in Wingin' It. He is also shocked when Flaky is injured and killed in Take Your Seat.
Like in many cases with other characters, The Mole has acted with obliviousness towards Mime. In Out of Sight, Out of Mime, he fails to notice Mime at his doorstep. In Chew Said a Mouthful, Mime is a customer at The Mole's hot dog stand until being killed by him. Mime is also annoyed when The Mole holds up the line in A Change of Heart. In Tunnel Vision, Mime has his eye impaled by a straw thanks to The Mole.
Mime doesn't really have a problem with Disco Bear, despite how the latter hates him. Mime laughs at Disco Bear for his baldness in Easy Comb, Easy Go. In Cubtron Z, however, they stand together and appear to enjoy each others company.
Mime is fired by Russell in Mime to Five after he kills his customers. Mime makes Russell a balloon sword in See What Develops. The two, in addition to Sniffles, are also actors in a school play in Something Fishy.
Considering their reputation, it can be assumed that Mime does not like Lifty and Shifty. The kleptomaniac duo steal Mime's (supposedly) imaginary safe in Easy For You to Sleigh, though Mime doesn't actually know it was them.
Mime clearly disliked Cro-Marmot for buying a unicycle he wanted in Mime to Five. Despite this, Mime is seen having a picnic with Cro-Marmot in Brake the Cycle, indicating a friendship between them. Mime also makes him a balloon hat in See What Develops and goes to Cro-Marmot's butcher shop in A Change of Heart.
- Main article: Flippy-Mime Relationship
Flippy, like Disco Bear, is another character Mime frequently annoys as seen in Keepin' it Reel and Random Acts of Silence. Mime also ignores Flippy at his birthday in Party Animal and instead tries to eat nuts from a blender.
Mime is shown to be a fan of Splendid's in Wrath of Con, happily walking up to the superhero in order to receive an autograph. Mime and Splendid meet again in Just Be Claus. Mime's desired Christmas gift was an inflatable punching bag with Splendid on it.
- He has yet to interact with Lammy and Mr. Pickels.
- Just like Nutty, Mime has irritated all of the bear characters at least once.