Cuddles is arguably the most well-known and popular character of the series. His relationships are the most prominent in the series as well as being the most frequent and explored. While a little mischievous, he is happy, optimistic and kind, which makes it no wonder he is friendly with many characters. Cuddles' reputation seems to be the most popular. Cuddles sometimes appears to be the sidekick of some characters, and other times he is seen as the leader of some groups. However, due to his innocence and his naive personality, he is an easy victim for manipulators and even murderers, such as Lifty, Shifty and Fliqpy. He is however, also known for his mischievous behavior, thing that annoys other characters sometimes. In fact, a lot of the characters have been annoyed by his mischief, even his own friends such as Lumpy, Toothy, Handy, Flaky, Petunia, or Sniffles.
- Main article: Cuddles-Giggles Relationship
Status: Best Friends/Couple
- Main article: Toothy-Cuddles Relationship
Status: Best Friends
Toothy is Cuddles' best friend, as has been shown in a number of episodes. In Blast from the Past, he played with Toothy and comforted him when he got hurt. In From A to Zoo, they teased animals together. They also threw snowballs in Strain Kringle. The one time they did not get along was Camp Pokeneyeout, due to a misunderstanding, but they redeemed their friendship in the end (though this was short-lived, as they are later crushed by a boulder in the same episode.) They are shown to still be best friends in Going Out With a Bang when they light fireworks together.
- Main article: Cuddles-Lumpy Relationship
Lumpy is shown to be a good friend of Cuddles. In Spin Fun Knowin' Ya and Blast from the Past, he brought Cuddles, along with Giggles and Toothy, to the playground. In Hear Today, Gone Tomorrow, he played with Cuddles and baked a cake for his birthday party. In Seize the Day, Cuddles and Lumpy play against each other on a video game.
In terms of negative reactions, Cuddles tells Toothy to throw a snowball at Lumpy in Strain Kringle. Cuddles was killed by Giant Lumpy in Dunce Upon a Time. Cuddles also had to deal with Lumpy repeatedly getting in his way of flirting with Giggles in The Carpal Tunnel of Love.
Despite how Petunia and Cuddles are both characters who appear in numerous episodes, they have never directly interacted (at least as of on-screen). They are only seen in big groups with other characters as seen in From A to Zoo, Kringle Feast, I Get a Trick Out of You, The Wrong Side of the Tracks, Take a Hike, and Home Is Where the Hurt Is. The most that could be said is that she served Cuddles burgers and fries in Flippin' Burgers, however she was annoyed by Cuddles, Toothy and Sniffles' mischief in Camp Pokeneyeout. Despite all that, Cuddles and Petunia are on good terms with each other and they get along really well.
Status: Minor enemies
Despite how Cuddles is usually friendly towards Handy, Handy gets easily annoyed by Cuddles' behavior.
In The Wrong Side of the Tracks Handy made fun of Cuddles when he lost his hands, and he didn't even care about Cuddles dying. In In a Jam, Cuddles admired Handy's band, however, Handy was clearly annoyed by Cuddles. First because of how bad he played the guitar and then because of Cuddles' antics that led to Handy's death. In Don't Yank My Chain, Cuddles was scared of seeing Handy in his well and caused him to drop all the way to the bottom again.
- Main article: Cuddles-Nutty Relationship
Status: Minor enemies
The relationship between Cuddles and Nutty seems to be at a neutral level but they seem to display somewhat of a mean-streak/disliking towards each other. Cuddles most likely dislikes Nutty after the events of Sweet Ride and False Alarm episode.
Both being Toothy's closest friends, Cuddles and Sniffles almost always appear with Toothy when together, in such episodes as Class Act, Remains to be Seen, From A to Zoo, Party Animal, and Take a Hike. In Wipe Out!, the two were briefly seen playing with a beach ball. However, on a more negative note, in Camp Pokeneyeout, Sniffles attacked Cuddles with his own invention after Cuddles attacked Toothy. Cuddles also annoys Sniffles by messing with the lights and subsequently getting Handy killed in In a Jam.
Just like Petunia, Cuddles and Pop appear in numerous episodes, but they never directly interacted. Their closest interaction together is in And the Kitchen Sink when Pop hit Cuddles with his car.
Their only interaction takes place in Cubtron Z. Cuddles is, for some reason, excited when Cubtron picks him up (most likely due to Cuddles' adventurous traits). Both characters were also suppose to eat a Christmas dinner in Kringle Feast.
Status: Best Friends
- Main article: Cuddles-Flaky Relationship
Cuddles and Flaky are shown to be very good friends on a number of occasions, such as in Water You Wading For, Let It Slide, The Wrong Side of the Tracks, and A Change of Heart. Cuddles is also happy to see Flaky in Take Your Seat and Happy New Year at the theaters. However, they usually are not compatible due to the former's reckless behavior and the latter's cautiousness.
Cuddles and The Mole seem to be friends for the most part. They both go to the same birthday parties in I Get a Trick Out of You and Party Animal. Both characters also work as firemen in Who's to Flame?.
However, sometimes, things do not go so well due to The Mole's blindness. Examples of this are in In a Jam, in which The Mole makes Cuddles give a second amount of blood, despite how he gave Cuddles a button the first time. Later, he accidentally kills Cuddles and mistakes him for a chair afterwards. In Home Is Where the Hurt Is, they operate a wood chipper together until the Mole unknowingly killed Cuddles. In A Sight for Sore Eyes, Cuddles watches as The Mole drops something in his drink, which makes him sick.
Cuddles dislikes Disco Bear for apparently kissing Giggles in YouTube 101: Subscriptions, and for hitting on her constantly. However, they work together in the fire brigade in Who's to Flame? and seem to have no problems with each other, that is until Disco Bear drives the firetruck without lowering the ladder first, getting Cuddles killed.
Cuddles is friends with Russell, as he was seen riding his ship along with several other characters in Snow Place to Go. They also play baseball with Toothy and Cro-Marmot in Can't Stop Coffin. They are seen in a group trick-or-treating in Remains to be Seen.
They appear in the same episode on several occasions but rarely interact. Their prime interaction and only negative one was Junk in the Trunk, where Cuddles unwittingly helps Lifty and Shifty with their scheme, until they steal his pet mouse and get him killed. They were also suppose to eat a Christmas dinner in Kringle Feast. They all even went trick-or-treating in Remains to be Seen. In Claw, Lifty and Shifty attempted to save Cuddles from the claw, which shows that they occasionally care about him.
Cuddles and Mime can be considered friends. They both appear together in Party Animal to help with Flippy's birthday and in Home Is Where the Hurt Is when they work together to build a house for Giggles. Cuddles buys a guitar from Mime in In a Jam.
Status: Friends (Enemies if Fliqpy)
Cuddles seems to be a fan of Splendid. He appears in Wrath of Con to listen to his speech, along with various other characters. He interacts with Splendid again in Just Be Claus when he gives him his Easter basket filled with eggs that need delivering, after getting sliced apart. It's unknown how Cuddles thinks off Splendid since the last thing he witnessed was Splendid tearing his ears off.
So far, the closest thing of an interaction between the two would be in You're Kraken Me Up, in which they stand beside each other watching Lumpy.
- Mr. Pickels is the only character Cuddles has yet to interact with.
- In addition to having several positive interactions with them, Cuddles has several similarities with Lifty and Shifty:
- They are all voiced by Kenn Navarro
- Both Cuddles and Shifty are the first characters to be created.
- They never survived a regular starring role.
- They have one of the lowest survival rates in the series
- They all died in their debut
- They died in the first and last episodes of the TV series.